Metastatic vulval Crohn's disease and infliximab: a case report.

Abstract

BACKGROUND:

Metastatic vulval Crohn's disease is uncommon, and diagnosis is frequently delayed. Topical therapy is often ineffective, and systemic immunosuppressive agents are required.

CASE:

A 32-year-old Caucasian female with known gastrointestinal Crohn's disease presented with a 7-year history of vulvitis. Perianal biopsy demonstrated typical granulomas. Her disease was resistant to treatment with prednisone and azathioprine; however, infliximab effected good control, and she remains well on 8 weekly infusions 1 year later.

CONCLUSION:

Biopsy should be performed in patients with vulvitis who have Crohn's disease to rule out metastatic involvement. Infliximab was successfully used in this case to control Crohn's vulvitis.

• Authors: Sara M Tritton, Liesel Whyte, Gayle Fischer
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 54 Issue 1 Pg. 41-4 (Jan 2009) ISSN: 0024-7758 [Print] United States
• PMID: 19263879 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Infliximab

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Crohn Disease (complications, drug therapy, pathology)
• Female
• Humans
• Infliximab
• Vulvitis (drug therapy, etiology, pathology)