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[A case of lymphocytic interstitial pneumonia complicated with primary Sjögren's syndrome followed by chest CT scanning for thirteen years].

Abstract
We encountered a rare case of lymphocytic interstitial pneumonia (LIP) complicated with primary Sjögren's syndrome (SjS), followed by chest CT scanning for a long period of time. A 54-year-old man with hemoptysis was admitted to our hospital in December, 2001. A diagnosis of SjS was made based on elevation of anti-SS-B/La antibody titer in serum in combination with diagnosis of keratoconjunctivitis sicca and xerostomia on a Schirmer test and a lip biopsy, respectively. Subsequent histopathological diagnosis by open lung biopsy showed LIP. Chest CT in September, 1995 at previous hospital revealed ground-glassed opacity (GGO), small nodules, thickened bronchovascular bundles and cyst formation in lungs. Chest CT was performed every year until 2008, when remarkable progression from thickened bronchovascular bundles accompanied by nodular opacities to an air-space consolidation in the right lower lobe was observed. Also, appearance of cyst formation in the right middle lobe, nodular lesions and GGO in the left lower lobe were noticed. Although the nodular opacities and GGO improved after an administration of corticosteroid (PSL 0.5 mg/kg/day), little improvement in the consolidations and cyst formation was demonstrated. In conclusion, it was suggested that differences among CT findings of LIP may be important for evaluating of efficacy of treatment by steroid agents for LIP associated with SjS.
AuthorsJun Tsukiji, Takeshi Kaneko, Masako Inoue, Toshinori Tsukahara, Yasumasa Shiobara, Masaru Ito, Harumi Koizumi, Akinori Nozawa, Masayoshi Kobayashi, Shuji Murakami, Koji Tomaru, Hideaki Oka, Masaki Yamamoto, Nobuaki Kobayashi, Hideto Goto, Makoto Kudo, Satoshi Inoue, Naoki Miyazawa, Yuji Watanuki, Yoshiaki Ishigatsubo
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 47 Issue 2 Pg. 151-7 (Feb 2009) ISSN: 1343-3490 [Print] Japan
PMID19260540 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Humans
  • Lung (radiography)
  • Lung Diseases, Interstitial (complications, pathology, radiography)
  • Lymphocytes (pathology)
  • Male
  • Middle Aged
  • Sjogren's Syndrome (complications)
  • Tomography, X-Ray Computed

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