[Semen descurainiae inhibits CYP11B1, CYP11B2 and TGF-beta1 mRNA expression in left ventricular].

Abstract

OBJECTIVE:

To investigate the effects of Semen descurainiae and Captopril on CYP11B1, CYP11B2 and TGF-beta1 mRNA expression of heart tissue in rats treated with Abdominal Aortic Banding.

METHODS:

Ventricular remodeling was induced by abdominal aortic banding (AAB) in rats. After 30 days' treatment, the ratios of LVW/BW (left ventricle weight/body weight), HW/BW (heart weight/body weight) were calculated; Then the CYP11B, CYP11B2 and TGF-beta1 mRNA expression of left ventricle were detected by Real-time PCR, respectively.

RESULTS:

The experimental data demonstrated that Semen descurainiae decreased the indexes of LVW/BW and HW/BW, down-regulated CYP11B, CYP11B2 and TGF-beta1 mRNA expression in left ventricle (P<0.05).

CONCLUSION:

Semen desceurainiae can significantly inhibit the experimental ventricular remodeling; the mechanism is related to its ability to attenuate the mRNA expression of CYP11B1, CYP11B2 and TGF-beta1 in left ventricle. The inhibition of aldosterone key gene expression by Semen descurainiae may contribute to its effect on restraint cardiac remodeling.

• Authors: Juan Guo, Chang-Xun Chen, Jun Du, Wei-Liang Gu, Yun-Hui Shen
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 31 Issue 11 Pg. 1691-5 (Nov 2008) ISSN: 1001-4454 [Print] China
• PMID: 19260283 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• RNA, Messenger
• Transforming Growth Factor beta
• Cytochrome P-450 CYP11B2
• Steroid 11-beta-Hydroxylase

Topics

• Animals
• Aorta, Abdominal (surgery)
• Brassicaceae (chemistry)
• Cardiomyopathy, Hypertrophic (etiology, metabolism, pathology)
• Cytochrome P-450 CYP11B2 (genetics, metabolism)
• Drugs, Chinese Herbal (pharmacology)
• Heart Ventricles (drug effects, metabolism)
• Male
• Myocardium (metabolism)
• Plants, Medicinal (chemistry)
• RNA, Messenger (genetics, metabolism)
• Rats
• Rats, Sprague-Dawley
• Seeds (chemistry)
• Steroid 11-beta-Hydroxylase (genetics, metabolism)
• Transforming Growth Factor beta (genetics, metabolism)
• Ventricular Remodeling (drug effects)