Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients.

Abstract

BACKGROUND:

Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC).

MATERIALS AND METHODS:

Patients undergoing resection for CRC (n = 175) were recruited from July 2003 to December 2004. MMP-7 was determined using a quantitative solid phase sandwich ELISA. Cox analysis was used to assess the role of MMP-7 in predicting overall survival (OS) and disease-free survival (DFS).

RESULTS:

The median length of follow-up was 45 months (range 1 to 59). Levels of MMP-7 are predictors of DFS (hazard ratio [HR] 1.119, 95% confidence interval [95% CI] 1.038-1.207) and of OS (HR 1.113, 95% CI 1.025-1.209). Patients with MMP-7 higher than the median (4.3 ng/ml) are more likely to relapse (29.5% vs 18.4%, P = .084); median time to progression in relapsed patients is 8 months if MMP-7 is > or =4.3 ng/ml and 18 months if MMP-7 is <4.3 ng/ml. Node-negative patients with low MMP-7 have a predicted probability of relapse-free survival at 4 years of 88% (95% CI 83-92%); if the MMP-7 is higher than the median value; this probability is 77% (95% CI 73-81%).

CONCLUSION:

MMP-7 predicts recurrence in curatively resected CRC patients.

• Authors: Alejandro Martínez-Fernandez, Xabier García-Albeniz, Estela Pineda, Laura Visa, Rosa Gallego, Jordi Codony-Servat, Josep Maria Augé, Raquel Longarón, Pere Gascón, Antonio Lacy, Antoni Castells, Joan Maurel
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 16 Issue 5 Pg. 1412-20 (May 2009) ISSN: 1534-4681 [Electronic] United States
• PMID: 19259740 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Matrix Metalloproteinase 7

Topics

• Adenocarcinoma (blood, mortality, therapy)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Colectomy
• Colorectal Neoplasms (blood, mortality, therapy)
• Combined Modality Therapy
• Female
• Humans
• Male
• Matrix Metalloproteinase 7 (blood)
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Survival Analysis