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[The radiation-sensitizing effect of isometronidazole following its intravesical application in bladder carcinoma. A clinical phase-II study].

Abstract
The radiosensitizing efficacy of iso-metronidazole, a 4-nitroimidazole derivative, was evaluated in a prospective clinical phase-II study. The results of combined radiotherapy of 25 patients with bladder cancer were compared with those of a control group of 25 patients treated with radiotherapy only. Tumor regression six months after radiotherapy was used as an endpoint. The surgical procedure was performed as double TUR. Evaluating the local tumor control after additional application of iso-metronidazole a gain factor of 1.2 is obtained.
AuthorsD Kob, A Lilienthal, H Bauhardt, K Merkle, E Schröder, E Schröder, M Hentschel
JournalStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 167 Issue 9 Pg. 530-3 (Sep 1991) ISSN: 0179-7158 [Print] Germany
Vernacular TitleDie strahlensensibilisierende Wirkung von iso-Metronidazol nach intravesikaler Applikation beim Harnblasenkarzinom. Eine klinische Phase-II-Studie.
PMID1925936 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Radiation-Sensitizing Agents
  • Metronidazole
  • isometronidazole
Topics
  • Administration, Intravesical
  • Combined Modality Therapy
  • Drug Evaluation
  • Female
  • Humans
  • Male
  • Metronidazole (administration & dosage, adverse effects, analogs & derivatives, pharmacokinetics)
  • Postoperative Care
  • Radiation-Sensitizing Agents (administration & dosage, adverse effects, pharmacokinetics)
  • Remission Induction
  • Urinary Bladder Neoplasms (blood, drug therapy, radiotherapy)

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