Abstract | BACKGROUND: METHODS: To assess the safety of low protein, we first conducted a nitrogen balance study in 34 incident PD patients randomized to receive in-centre diets containing 1.2, 0.9 or 0.6 g of protein/kg ideal body weight (IBW)/day for 10 days. Second, 60 stable PD patients [RRF 4.04 +/- 2.30 ml/ min/1.73 m(2), urine output 1226 +/- 449 ml/day, aged 53.6 +/- 12.8 years, PD duration 8.8 (1.5-17.8) months] were randomized to receive either a low- (LP: 0.6-0.8 g/kg IBW/day), keto acid-supplemented low- (sLP: 0.6-0.8 g/kg IBW/day with 0.12 g/kg IBW/day of keto acids) or high- protein (HP: 1.0-1.2 g/kg IBW/day) diet. The groups were followed for 1 year and RRF as well as nutritional status was evaluated serially. RESULTS: A neutral or positive nitrogen balance was achieved in all three groups. RRF remained stable in group sLP (3.84 +/- 2.17 to 3.39 +/- 3.23 ml/min/1.73 m(2), P = ns) while it decreased in group LP (4.02 +/- 2.49 to 2.29 +/- 1.72 ml/min/1.73 m(2), P < 0.05) and HP (4.25 +/- 2.34 to 2.55 +/- 2.29 ml/min/1.73 m(2), P < 0.05). There was no change from baseline on nutritional status in any of the groups during follow-up. CONCLUSIONS: A diet containing 0.6-0.8 g of protein/kg IBW/day is safe and, when combined with keto acids, is associated with an improved preservation of RRF in relatively new PD patients without significant malnutrition or inflammation.
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Authors | Na Jiang, Jiaqi Qian, Weilan Sun, Aiwu Lin, Liou Cao, Qin Wang, Zhaohui Ni, Yanping Wan, Bengt Linholm, Jonas Axelsson, Qiang Yao |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 24
Issue 8
Pg. 2551-8
(Aug 2009)
ISSN: 1460-2385 [Electronic] England |
PMID | 19258386
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Proteins
- Keto Acids
- Nitrogen
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Dietary Proteins
(administration & dosage)
- Dietary Supplements
- Female
- Follow-Up Studies
- Humans
- Keto Acids
(metabolism)
- Kidney Failure, Chronic
(diet therapy, metabolism)
- Kidney Function Tests
- Male
- Middle Aged
- Nitrogen
(metabolism)
- Peritoneal Dialysis
(methods)
- Prospective Studies
- Tissue Distribution
- Young Adult
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