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Bioactive alkaloids from endophytic Aspergillus fumigatus.

Abstract
Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC(50) value of 3.1 microM, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration.
AuthorsHui Ming Ge, Zhi Guo Yu, Jie Zhang, Jun Hua Wu, Ren Xiang Tan
JournalJournal of natural products (J Nat Prod) Vol. 72 Issue 4 Pg. 753-5 (Apr 2009) ISSN: 1520-6025 [Electronic] United States
PMID19256529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 14-norpseurotin
  • 9-deacetoxyfumigaclavine C
  • 9-deacetylfumigaclavine C
  • Antineoplastic Agents
  • Indole Alkaloids
  • Nerve Growth Factors
  • Spiro Compounds
Topics
  • Animals
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Aspergillus fumigatus (chemistry)
  • Cynodon (microbiology)
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Indole Alkaloids (chemistry, isolation & purification, pharmacology)
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nerve Growth Factors (chemistry, isolation & purification, pharmacology)
  • PC12 Cells
  • Rats
  • Spiro Compounds

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