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Effect of [10]-gingerol on [ca2+]i and cell death in human colorectal cancer cells.

Abstract
The effect of [10]-gingerol on cytosol free Ca(2+) concentration ([Ca(2+)](i)) and viability is large unknown. This study examines the early signaling effects of [10]-gingerol on human colorectal cancer cells. It was found that this compound caused a slow and sustained rise of [Ca(2+)](i) in a concentration-dependent manner. [10]-Gingerol also induced a [Ca(2+)](i) rise when extracellular Ca(2+) was removed, but the magnitude was reduced by 38%. In a Ca(2+)-free medium, the [10]-gingerol-induced [Ca(2+)](i) rise was partially abolished by depleting stored Ca(2+) with thapsigargin (an endoplasmic reticulum Ca(2+) pump inhibitor). The elevation of [10]-gingerol-caused [Ca(2+)](i) in a Ca(2+)-containing medium was not affected by modulation of protein kinase C activity. The [10]-gingerol-induced Ca(2+) influx was insensitive to L-type Ca(2+) channel blockers. At concentrations of 10-100 mM, [10]-gingerol killed cells in a concentration-dependent manner. These findings suggest that [10]-gingerol induces [Ca(2+)](i) rise by causing Ca(2+) release from the endoplasmic reticulum and Ca(2+) influx from non-L-type Ca(2+) channels in SW480 cancer cells.
AuthorsChung-Yi Chen, Yi-Wen Li, Soong-Yu Kuo
JournalMolecules (Basel, Switzerland) (Molecules) Vol. 14 Issue 3 Pg. 959-69 (Mar 02 2009) ISSN: 1420-3049 [Electronic] Switzerland
PMID19255554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Calcium Channels, L-Type
  • Catechols
  • Fatty Alcohols
  • gingerol
  • Protein Kinase C
  • Calcium
Topics
  • Antineoplastic Agents
  • Calcium (metabolism)
  • Calcium Channels, L-Type
  • Catechols (pharmacology, therapeutic use)
  • Cell Survival (drug effects)
  • Colorectal Neoplasms (drug therapy, pathology)
  • Endoplasmic Reticulum (metabolism)
  • Fatty Alcohols (pharmacology, therapeutic use)
  • Humans
  • Protein Kinase C (metabolism)
  • Tumor Cells, Cultured

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