Multiple extrauterine adenomyomas and uterus-like masses: case reports and review of the literature.

Abstract

OBJECTIVE:

To describe two rare cases of multiple extrauterine adenomyomas, their clinical management, and their response to surgical and hormone therapy with GnRH agonist.

DESIGN:

Case report and review of the English-language scientific literature.

SETTING:

Cases presented in a tertiary health care academic institution.

PATIENT(S):

Two patients without urogenital malformations diagnosed with extrauterine adenomyoma, which is a benign tumor composed of smooth muscle and endometrium, typically originating within the uterus.

INTERVENTION(S):

Surgical radical excision of adenomyomas followed by a long-term hormone therapy with GnRH agonist.

MAIN OUTCOME MEASURE(S):

Anatomical and clinical outcomes.

RESULT(S):

Surgical treatment followed by long-term GnRH agonist therapy appeared effective in keeping the disease stable. After a long-term follow-up of 10 and 4 years, the two patients are still asymptomatic and stable.

CONCLUSION(S):

Only 19 other cases of extrauterine adenomyomas are reported in the English-language scientific literature, and no cases of multiple masses are described until now. It is probable that these extrauterine adenomyomas arose from a metaplastic transformation of the subcelomic mesenchyme. Long-term GnRH agonist therapy after surgery appeared effective in keeping the disease stable.

• Authors: Silvestro Carinelli, Francesca Motta, Giada Frontino, Elisa Restelli, Luigi Fedele
• Journal: Fertility and sterility (Fertil Steril) Vol. 91 Issue 5 Pg. 1956.e9-11 (May 2009) ISSN: 1556-5653 [Electronic] United States
• PMID: 19254794 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Gonadotropin-Releasing Hormone

Topics

• Adenomyoma (pathology, therapy)
• Adult
• Combined Modality Therapy
• Female
• Gonadotropin-Releasing Hormone (agonists)
• Humans
• Intestinal Neoplasms (pathology, therapy)
• Middle Aged
• Uterus (pathology)