Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia.

Abstract

OBJECTIVE:

This study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor-beta1 (TGF-beta1) according to preeclamptic complications and to investigate the correlation between these factors and the clinical symptoms of preeclampsia.

METHOD:

We estimated the levels of sEng and TGF-beta1 in plasma collected in the second trimester at the time of genetic amniocentesis from 60 women who subsequently developed preeclampsia and 124 contemporaneous normotensive women.

RESULTS:

sEng levels were higher in cases than in controls, whereas TGF-beta1 levels were lower (P < 0.001). sEng levels, but not TGF-beta1 levels, were higher in cases with severe or preterm delivery than in cases with mild preeclampsia or term delivery (P < 0.001) and were increased in cases destined to deliver a small gestational age neonate (P < 0.001). Moreover, sEng levels, but not TGF-beta1 levels, showed a positive correlation with maximum diastolic and systolic blood pressure (r = 0.57, P < 0.001; and r = 0.33, P < 0.001, respectively) and proteinuria (r = 0.42, P < 0.001).

CONCLUSION:

Early midtrimester plasma levels of sEng are predictive of subsequence occurrence and severity of preeclampsia, in terms of severity of hypertension and proteinuria, prematurity, and association with small for gestational age neonates.

• Authors: Ji Hyae Lim, Shin Young Kim, So Yeon Park, Moon Hee Lee, Jae Hyug Yang, Moon Young Kim, Jin Hoon Chung, Si Won Lee, Hyun Mee Ryu
• Journal: Prenatal diagnosis (Prenat Diagn) Vol. 29 Issue 5 Pg. 471-6 (May 2009) ISSN: 1097-0223 [Electronic] England
• PMID: 19253312 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2009 John Wiley & Sons, Ltd.

Chemical References

• Antigens, CD
• ENG protein, human
• Endoglin
• Receptors, Cell Surface
• Transforming Growth Factor beta1

Topics

• Adult
• Antigens, CD (blood)
• Case-Control Studies
• Diagnostic Techniques, Obstetrical and Gynecological
• Endoglin
• Female
• Humans
• Infant, Newborn
• Infant, Small for Gestational Age
• Pre-Eclampsia (blood, diagnosis, etiology, physiopathology)
• Pregnancy
• Pregnancy Trimester, Second (blood)
• Prognosis
• Receptors, Cell Surface (blood)
• Sensitivity and Specificity
• Severity of Illness Index
• Transforming Growth Factor beta1 (blood)