HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Hemophagocytic syndrome as primary manifestation in a patient with systemic lupus erythematosus after parturition].

Abstract
A 33-year-old woman presented with fever, malar rash, lymphadenopathy and pancytopenia 3 weeks after parturition. Serum C3 level was decreased and antinuclear antibody, anti-dsDNA antibody and anti-SS-A antibody were positive. Serum ferritin level was elevated (3454 ng/ml), and bone marrow aspirate revealed hemophagocytosis. She was diagnosed having systemic lupus erythematosus (SLE) associated with hemophagocytic syndrome (HPS). Oral prednisolone (55 mg/day) was initiated. Clinical manifestations and pancytopenia were improved and serum ferritin level was decreased. However, elevated anti-dsDNA antibody titer and reduced C3 level continued for a month after steroid therapy. The additional therapy of tacrolimus (3 mg/day) improved clinical and laboratory findings. This is a rare SLE case associated with HPS as primary manifestation after parturition.
AuthorsShuzo Yoshida, Tohru Takeuchi, Yasuo Itami, Kenichiro Hata, Koko Watanabe, Takeshi Shoda, Takuya Kotani, Shigeki Makino, Toshiaki Hanafusa
JournalNihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Nihon Rinsho Meneki Gakkai Kaishi) Vol. 32 Issue 1 Pg. 66-70 (Feb 2009) ISSN: 1349-7413 [Electronic] Japan
PMID19252381 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Topics
  • Adult
  • Female
  • Humans
  • Lupus Erythematosus, Systemic (complications)
  • Lymphohistiocytosis, Hemophagocytic (etiology)
  • Pregnancy
  • Puerperal Disorders

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: