Once- versus twice-weekly changing of central venous catheter occlusive dressing in intensive chemotherapy patients: results of a randomized multicenter study.

Abstract

BACKGROUND:

Changing a central venous catheter occlusive dressing on a twice-weekly basis is usually recommended in hemato-oncological patients. A longer interval is believed to give rise to infections. However, frequent dressing changes might cause local cutaneous damage.

MATERIAL/METHODS:

Local cutaneous damage and infections were compared in patients with once-weekly versus twice-weekly changes of central venous catheters occlusive dressings. This was a prospective, randomized, multicenter trial.

RESULTS:

Eighty-one patients with acute myeloid leukemia being treated with intensive chemotherapy were enrolled (twice-weekly group: n=42, once-weekly group: n=39). They had a non-tunneled polyurethane central venous catheter inserted into the vena subclavia and the insertion site was covered by a polyurethane semi-permeable occlusive dressing. No differences were observed between the groups with respect to local cutaneous damage, fevers, or positive catheter blood cultures. There were more insertion-site inflammations in the twice-weekly group (55% vs. 25%, p=0.008). In the once-weekly group it was necessary to change the occlusive dressing sooner in 42% of the cases, mostly due to a soiled dressing and local bleeding, and the real mean interval of changes was 5.4 days.

CONCLUSIONS:

Prolonging the frequency of occlusive dressing change to a once-weekly interval was limited by an increasing number of unplanned dressing changes. The prolonged interval of dressing changes, with a real mean interval of 5.4 days, did not lead to an increased number of local cutaneous complications or central venous catheter blood culture positivity and even contributed to reduced insertion-site inflammation occurrence.

• Authors: Samuel Vokurka, Eva Bystricka, Maria Visokaiova, Jana Scudlova
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 15 Issue 3 Pg. CR107-10 (Mar 2009) ISSN: 1643-3750 [Electronic] United States
• PMID: 19247240 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Topics

• Catheter-Related Infections (blood, complications, microbiology)
• Catheterization, Central Venous (adverse effects)
• Female
• Fever (complications)
• Humans
• Inflammation (complications)
• Leukemia, Myeloid, Acute (complications, drug therapy)
• Male
• Middle Aged
• Occlusive Dressings (adverse effects)
• Pain (complications)
• Skin (pathology)
• Time Factors