Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed.

Abstract	Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.
Authors	Saikat Dewanjee, Anup Maiti, Anup K Das, Subhash C Mandal, Sankar P Dey
Journal	Fitoterapia (Fitoterapia) Vol. 80 Issue 4 Pg. 249-51 (Jun 2009) ISSN: 1873-6971 [Electronic] Netherlands
PMID	19239921 (Publication Type: Journal Article)
Chemical References	Hypoglycemic Agents Limonins Plant Extracts swietenine
Topics	Animals Diabetes Mellitus, Experimental (drug therapy) Dose-Response Relationship, Drug Hypoglycemic Agents (isolation & purification, pharmacology, therapeutic use) Limonins (isolation & purification, pharmacology, therapeutic use) Meliaceae (chemistry) Phytotherapy Plant Extracts (chemistry, pharmacology, therapeutic use) Rats Rats, Wistar Seeds

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