The anticonvulsive effect of BCH 325 is age dependent.

Abstract	The two different experimental approaches which were applied to study the anticonvulsive effectiveness of BCH 325, a des-tyrosine derivative of bovine beta-casomorphin-(5), in immature (22-day-old) and mature (7-week-old) female rats revealed that the peptide was able to protect mature females from electrically induced seizures and that it had no effect on pentylenetetrazol-induced convulsions. As opposed to this, immature animals were protected against chemically induced seizures but no effect was found using electrically induced seizures.
Authors	A Becker, R Grimm, G Grecksch, H Matthies
Journal	Peptides (Peptides) 1991 May-Jun Vol. 12 Issue 3 Pg. 669-70 ISSN: 0196-9781 [Print] United States
PMID	1923942 (Publication Type: Journal Article)
Chemical References	Anticonvulsants Endorphins Peptide Fragments beta-casomorphin, des-Tyr- Pentylenetetrazole
Topics	Age Factors Animals Anticonvulsants Electroshock Endorphins (pharmacology) Female Pentylenetetrazole Peptide Fragments (pharmacology) Rats Rats, Inbred Strains Seizures (prevention & control)

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