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[Pharmacovigilance and teratovigilance 2008].

Abstract
Various signals and alerts of pharmacovigilance were issued in 2008. Frequent neuropsychiatric adverse events are reported with varenicline and rimonabant and the marketing authorization of the latter has been suspended. Ezetimibe/simvastatin combination is suspected of causing cancer while it's clinical utility remains to be proved. Neuroleptics, typical and atypical, are associated with an increased risk of death in elderly with dementia. Safety is a concern with various biological drugs. Rituximab, natalizumab and efalizumab are involved in rare cases of progressive multifocal leukoencephalopathy with fatal issue. Screening of HLA-B*5701, a good predictor of hypersensitivity reaction to abacavir, is recommended prior to starting therapy. Mycophenolate turns out to be a human teratogen.
AuthorsFrançoise Livio, Anton Ivanyuk, Jérôme Biollaz
JournalRevue medicale suisse (Rev Med Suisse) Vol. 5 Issue 186 Pg. 130-4 (Jan 14 2009) ISSN: 1660-9379 [Print] Switzerland
Vernacular TitlePharmacovigilance et teratovigilance 2008.
PMID19238932 (Publication Type: English Abstract, Journal Article)
Topics
  • Abnormalities, Drug-Induced (prevention & control)
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Product Surveillance, Postmarketing

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