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Toxoplasmosis in HIV/AIDS patients in Malaysia.

AbstractThree hundred and one sera of HIV/AIDS patients were tested for anti-Toxoplasma IgG antibody by ELISA technique. The seroprevalence of toxoplasmosis was 41.2% (95% CI: 35.5-46.9) in HIV/AIDS patients. The seroprevalence was significantly higher in the Malay (57.9%) than the Chinese (38.7%), followed by the Indian patients (29.6%) (p<0.05). No possible risk factor, such as contact with cats, consumption of uncooked meat, and history of blood transfusions was found to have any significant association with the presence of anti-Toxoplasma antibody in the study sample (p>0.05). Multivariate analysis was employed to find any association between Toxoplasma seroprevalence and a single subject having single or multiple risk factors. It was found that the association was not statistically significant (p>0.05). Among the HIV/AIDS study samples, 124 (41.2%) samples were found to have positive anti-Toxoplasma antibody, the association between the presence of anti-Toxoplasma antibody and CD4 cell count was determined but no statistically significant association was found (p>0.05). During the study period, only one case of active CNS toxoplasmosis was registered and the diagnostic criteria included: clinical presentations, CT scan finding, serological evidence of anti-Toxoplasma IgG antibody, and respose to anti-Toxoplasma therapy.
AuthorsV Nissapatorn, C K C Lee, S M Cho, M Rohela, A Khirul Anuar, K F Quek, H M Latt (Affiliation: Department of Parasitology, University of Malaya Medical Center, Kuala Lumpur, Malaysia. nissapat at hotmail.com)
JournalThe Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 34 Suppl 2 Pg. 80-5 ( 2003) ISSN: 0125-1562 [Print] Thailand
PMID19238664 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Protozoan
Topics
  • Acquired Immunodeficiency Syndrome (complications)
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Protozoan (blood)
  • Blotting, Western
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Malaysia (epidemiology)
  • Male
  • Middle Aged
  • Risk Factors
  • Seroepidemiologic Studies
  • Socioeconomic Factors
  • Toxoplasmosis (complications, epidemiology)
  • Young Adult