Abstract | BACKGROUND: Tracheal intubation during sevoflurane induction is frequently facilitated with i.v. propofol. We designed a dose-response study to evaluate the intubating conditions, and the incidence and duration of apnea after i.v. propofol in children. METHODS/MATERIALS: Sixty healthy children were randomly assigned to 0, 0.5, 1, 2 or 3 mg x kg(-1) i.v. propofol during sevoflurane/ nitrous oxide anesthesia. Tracheal intubation was performed approximately 30 s after propofol by an anesthesiologist who was blind to the treatment. The anesthesiologist assessed the responses to laryngoscopy and intubation using a standardized scale. Incidence and duration of apnea after propofol as well as heart rate, and systolic blood pressure before and after laryngoscopy were recorded. Data were analyzed using one-way and repeated measures ANOVA, the Jonckheere-Terpstra test, and logistic regression, with P < 0.05 accepted. RESULTS: The laryngoscopy score after 3 mg x kg(-1) propofol was less than that after 0 mg x kg(-1) (P < 0.01) and 0.5 mg x kg(-1) (P < 0.05). Incidence of apnea after propofol 3 mg x kg(-1), 8/10, was greater than after 0 mg x kg(-1), 3/14 (P < 0.011) and 0.5 mg x kg(-1), 3/12 (P < 0.03). Duration of apnea after 3 mg x kg(-1) was greater than after 0 and 0.5 mg x kg(-1) (P < 0.01). The risk of apnea increased 1.83 fold for each 1 mg x kg(-1) dose increase in propofol (P < 0.01). Mean heart rate and systolic pressure decreased with the main effect, time. CONCLUSION:
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Authors | Jerrold Lerman, Timothy T Houle, Benjamin T Matthews, James Houck, Frederick A Burrows |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 19
Issue 3
Pg. 218-24
(Mar 2009)
ISSN: 1460-9592 [Electronic] France |
PMID | 19236643
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Sevoflurane
- Nitrous Oxide
- Propofol
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Topics |
- Adenoidectomy
- Anesthesia, General
- Anesthesia, Intravenous
- Anesthetics, Inhalation
- Apnea
(therapy)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Female
- Hemodynamics
- Humans
- Intubation, Intratracheal
(methods)
- Laryngoscopy
- Male
- Methyl Ethers
- Nitrous Oxide
- Propofol
- Sample Size
- Sevoflurane
- Tonsillectomy
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