Abstract |
We isolated several stilbene compounds including rhaponticin (3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice. In this study, we investigated the effect of rhaponticin on glucose utilization, lipid metabolism, and liver and heart function in a KK/Ay type 2 diabetic mouse model. The results showed that oral administration of rhaponticin (125 mg/kg) significantly reduced blood glucose levels and improved oral glucose tolerance of KK/Ay diabetic mice. Elevated plasma triglyceride (TG), low density lipoprotein ( LDL), cholesterol (CHO), non-esterified free fatty acids ( NEFA), and insulin levels were also markedly attenuated. Serum enzymatic activities of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the rhaponticin-treated group significantly decreased in comparison to the untreated model group. Livers of rhaponticin-treated mice had relatively normal cellular size and decreased fibrosis and steatosis. In addition, rhaponticin administration caused a remarkable increase in the hepatic glycogen content and a significant reduction in the hepatic triglyceride content. These results indicate that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.
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Authors | Jinlong Chen, Mengmeng Ma, Yanwei Lu, Lisheng Wang, Chutse Wu, Haifeng Duan |
Journal | Planta medica
(Planta Med)
Vol. 75
Issue 5
Pg. 472-7
(Apr 2009)
ISSN: 1439-0221 [Electronic] Germany |
PMID | 19235684
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Enzymes
- Fatty Acids, Nonesterified
- Hypoglycemic Agents
- Insulin
- Lipids
- Lipoproteins, LDL
- Stilbenes
- Triglycerides
- Glycogen
- Cholesterol
- rhapontin
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Cholesterol
(blood)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Enzymes
(blood)
- Fatty Acids, Nonesterified
(blood)
- Fatty Liver
(drug therapy, metabolism)
- Glucose Tolerance Test
- Glycogen
(metabolism)
- Hypoglycemic Agents
(isolation & purification, pharmacology, therapeutic use)
- Insulin
(blood)
- Lipids
(blood)
- Lipoproteins, LDL
(blood)
- Liver
(drug effects, metabolism, pathology)
- Mice
- Rheum
(chemistry)
- Rhizome
- Stilbenes
(isolation & purification, pharmacology, therapeutic use)
- Triglycerides
(blood)
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