Abstract | PURPOSE: The present study was undertaken to clarify the participation of the GABA-ergic system in epileptogenic activity induced by teicoplanin. METHODS: Under pentobarbital anesthesia, mice were fixed to a stereotaxic apparatus, and stainless steel electrodes were implanted into the frontal cortex (FCOR), hippocampus (HPC) and amygdala (AMG). Behavioral and electroencephalographic (EEG) changes were observed for 60min following teicoplanin intracerebroventricular (i.c.v.) injection. RESULTS: CONCLUSIONS:
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Authors | Kenshi Takechi, Akinori Fujiwara, Yusuke Watanabe, Chiaki Kamei |
Journal | Epilepsy research
(Epilepsy Res)
Vol. 84
Issue 2-3
Pg. 127-34
(Apr 2009)
ISSN: 1872-6844 [Electronic] Netherlands |
PMID | 19233620
(Publication Type: Journal Article)
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Chemical References |
- (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid
- Anti-Bacterial Agents
- Excitatory Amino Acid Antagonists
- GABA Antagonists
- Nipecotic Acids
- Oximes
- Phosphinic Acids
- Pyridines
- NNC 711
- gamma-Aminobutyric Acid
- Teicoplanin
- Dizocilpine Maleate
- Bicuculline
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Topics |
- Animals
- Anti-Bacterial Agents
(toxicity)
- Bicuculline
(administration & dosage)
- Brain
(drug effects, physiology)
- Disease Models, Animal
- Dizocilpine Maleate
(therapeutic use)
- Electric Stimulation
(adverse effects)
- Electroencephalography
(methods)
- Epilepsy
(chemically induced, drug therapy, pathology, prevention & control)
- Excitatory Amino Acid Antagonists
(therapeutic use)
- GABA Antagonists
(therapeutic use)
- Male
- Mice
- Mice, Inbred ICR
- Nipecotic Acids
(therapeutic use)
- Oximes
(therapeutic use)
- Phosphinic Acids
(administration & dosage)
- Pyridines
(administration & dosage)
- Teicoplanin
(toxicity)
- gamma-Aminobutyric Acid
(metabolism)
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