A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study.

Abstract

BACKGROUND & AIM:

The addition of prebiotics to infant formula modifies the composition of intestinal microflora. Aim of the study was to test the hypothesis that prebiotics reduce the incidence of intestinal and respiratory infections in healthy infants.

METHODS:

A prospective, randomized, placebo-controlled, open trial was performed. Healthy infants were enrolled and randomized to a formula additioned with a mixture of galacto- and fructo-oligosaccharides or to a control formula. The incidence of intestinal and respiratory tract infections and the anthropometric measures were monitored for 12 months.

RESULTS:

Three hundred and forty two infants (mean age 53.7+/-32.1 days) were enrolled. The incidence of gastroenteritis was lower in the supplemented group than in the controls (0.12+/-0.04 vs. 0.29+/-0.05 episodes/child/12 months; p=0.015). The number of children with more than 3 episodes tended to be lower in prebiotic group (17/60 vs. 29/65; p=0.06). The number of children with multiple antibiotic courses/year was lower in children receiving prebiotics (24/60 vs. 43/65; p=0.004). A transient increase in body weight was observed in children on prebiotics compared to controls during the first 6 months of follow-up.

CONCLUSIONS:

Prebiotic administration reduce intestinal and, possibly, respiratory infections in healthy infants during the first year of age.

• Authors: Eugenia Bruzzese, Monica Volpicelli, Veronica Squeglia, Dario Bruzzese, Filippo Salvini, Massimo Bisceglia, Paolo Lionetti, Mario Cinquetti, Giuseppe Iacono, Sergio Amarri, Alfredo Guarino
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 28 Issue 2 Pg. 156-61 (Apr 2009) ISSN: 1532-1983 [Electronic] England
• PMID: 19231042 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Oligosaccharides
• Sweetening Agents
• Fructose
• Galactose

Topics

• Case-Control Studies
• Female
• Follow-Up Studies
• Fructose (administration & dosage)
• Galactose (administration & dosage)
• Gastroenteritis (immunology, prevention & control)
• Humans
• Infant
• Infant Formula (chemistry, methods)
• Infection Control (methods, statistics & numerical data)
• Infections (immunology)
• Intestines (immunology)
• Male
• Oligosaccharides (administration & dosage)
• Probiotics (administration & dosage)
• Prospective Studies
• Respiratory Tract Infections (immunology, prevention & control)
• Sweetening Agents (administration & dosage)