HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Autologous attenuated T-cell vaccine (Tovaxin) dose escalation in multiple sclerosis relapsing-remitting and secondary progressive patients nonresponsive to approved immunomodulatory therapies.

Abstract
An open-label dose escalation study of T-cell vaccination in multiple sclerosis patients was conducted using attenuated myelin reactive T-cells (MRTC) selected with six myelin peptides, two each from MBP, PLP and MOG. The dose range of subcutaneous injections given at weeks 0, 4, 12 and 20 was 6-9E6, 30-45E6 and 60-90E6 irradiated MRTC. Assessments were over 52 weeks for MRTC levels, EDSS, MSIS-29, brain MRI and relapses. The 30-45E6 dose was the most effective with reductions in MRTC ranging from 92.4% at week 5 to 64.8% at week 52. The reduction in relapses compared to baseline for the M-ITT and evaluable per-protocol analyses were 63.5%, and 85.0% at week 52. The MRI lesions were stable while there was an improvement trend in the EDSS and MSIS-29 physical subscore following the second injection. Adverse events were mild to moderate in intensity with mild injection site reactions occurring with increasing dosage. The mid-dose was selected for further clinical development studies because of the rapid depletion of peripheral blood MRTC and a trend for improvements in clinical outcomes following immunization.
AuthorsB Loftus, B Newsom, M Montgomery, K Von Gynz-Rekowski, M Riser, S Inman, P Garces, D Rill, J Zhang, J C Williams
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 131 Issue 2 Pg. 202-15 (May 2009) ISSN: 1521-7035 [Electronic] United States
PMID19230777 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Immunologic Factors
  • Myelin Basic Protein
  • Vaccines
  • Vaccines, Attenuated
  • Vaccines, Subunit
  • tovaxin
Topics
  • Adult
  • Dose-Response Relationship, Drug
  • Humans
  • Immunologic Factors (adverse effects, therapeutic use)
  • Immunotherapy (standards)
  • Infusions, Subcutaneous
  • Multiple Sclerosis, Relapsing-Remitting (drug therapy, physiopathology)
  • Myelin Basic Protein (genetics, immunology)
  • T-Lymphocytes (immunology)
  • Treatment Outcome
  • Vaccines
  • Vaccines, Attenuated (therapeutic use)
  • Vaccines, Subunit (adverse effects, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: