Abstract |
The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient (P < 0.0001). Also, the levels of agreement for the results for itraconazole, fluconazole, and ketoconazole were 84%, 90%, and 98% (P < 0.0001), respectively. Multilocus typing by PCR fingerprinting and subsequent cluster analysis delineated geographically associated alignments for Candida albicans and fluconazole resistance-related clusters for Candida glabrata.
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Authors | Stavroula Antonopoulou, Michel Aoun, Evangelos C Alexopoulos, Stavroula Baka, Emanuel Logothetis, Theodoros Kalambokas, Andreas Zannos, Konstantine Papadias, Odysseas Grigoriou, Evangelia Kouskouni, Aristea Velegraki |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 53
Issue 5
Pg. 2181-4
(May 2009)
ISSN: 1098-6596 [Electronic] United States |
PMID | 19223627
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Imidazoles
- Itraconazole
- Fluconazole
- fenticonazole
- Ketoconazole
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Topics |
- Adult
- Antifungal Agents
(pharmacology)
- Candida albicans
(classification, drug effects, genetics)
- Candida glabrata
(classification, drug effects, genetics)
- Candidiasis, Vulvovaginal
(epidemiology, microbiology)
- Cluster Analysis
- DNA Fingerprinting
(methods)
- Drug Resistance, Fungal
- Europe
(epidemiology)
- Female
- Fluconazole
(pharmacology)
- Genotype
- Humans
- Imidazoles
(pharmacology)
- Itraconazole
(pharmacology)
- Ketoconazole
(pharmacology)
- Microbial Sensitivity Tests
(methods, standards)
- Polymerase Chain Reaction
- Pregnancy
- Pregnancy Complications, Infectious
(epidemiology, microbiology)
- Prevalence
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