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Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.

Abstract
The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient (P < 0.0001). Also, the levels of agreement for the results for itraconazole, fluconazole, and ketoconazole were 84%, 90%, and 98% (P < 0.0001), respectively. Multilocus typing by PCR fingerprinting and subsequent cluster analysis delineated geographically associated alignments for Candida albicans and fluconazole resistance-related clusters for Candida glabrata.
AuthorsStavroula Antonopoulou, Michel Aoun, Evangelos C Alexopoulos, Stavroula Baka, Emanuel Logothetis, Theodoros Kalambokas, Andreas Zannos, Konstantine Papadias, Odysseas Grigoriou, Evangelia Kouskouni, Aristea Velegraki
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 5 Pg. 2181-4 (May 2009) ISSN: 1098-6596 [Electronic] United States
PMID19223627 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Imidazoles
  • Itraconazole
  • Fluconazole
  • fenticonazole
  • Ketoconazole
Topics
  • Adult
  • Antifungal Agents (pharmacology)
  • Candida albicans (classification, drug effects, genetics)
  • Candida glabrata (classification, drug effects, genetics)
  • Candidiasis, Vulvovaginal (epidemiology, microbiology)
  • Cluster Analysis
  • DNA Fingerprinting (methods)
  • Drug Resistance, Fungal
  • Europe (epidemiology)
  • Female
  • Fluconazole (pharmacology)
  • Genotype
  • Humans
  • Imidazoles (pharmacology)
  • Itraconazole (pharmacology)
  • Ketoconazole (pharmacology)
  • Microbial Sensitivity Tests (methods, standards)
  • Polymerase Chain Reaction
  • Pregnancy
  • Pregnancy Complications, Infectious (epidemiology, microbiology)
  • Prevalence

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