Abstract | BACKGROUND: METHODS: Forty-six healthy term parturients scheduled for cesarean delivery were randomized to receive 500 mL of 6% hetastarch intravenously, either slowly before spinal anesthesia (pre-loading) or as quickly as possible immediately after spinal anesthesia (co-loading). Systolic blood pressure was maintained at or above 90% of baseline with intravenous vasopressor boluses ( ephedrine 5mg/mL+phenylephrine 25 microg/mL). The primary outcome was the volume of vasopressor mix required. Secondary outcomes included blood pressure and heart rate changes, time to first vasopressor use, nausea or vomiting, and neonatal outcomes (umbilical artery and vein pH, Apgar scores). RESULTS: The pre-loading group used 3.5+/-2 mL (mean+/-SD) of vasopressor mixture compared with 3.2+/-3 mL in the co-loading group (P=0.6). There were no differences in any important maternal hemodynamic or neonatal outcome values between the two study groups. CONCLUSION:
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Authors | B Carvalho, F J Mercier, E T Riley, C Brummel, S E Cohen |
Journal | International journal of obstetric anesthesia
(Int J Obstet Anesth)
Vol. 18
Issue 2
Pg. 150-5
(Apr 2009)
ISSN: 1532-3374 [Electronic] Netherlands |
PMID | 19223168
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Hydroxyethyl Starch Derivatives
- Plasma Substitutes
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Topics |
- Adolescent
- Adult
- Anesthesia, Obstetrical
- Anesthesia, Spinal
- Apgar Score
- Blood Pressure
(drug effects, physiology)
- Cesarean Section
- Double-Blind Method
- Female
- Fetal Blood
(chemistry)
- Heart Rate
(drug effects, physiology)
- Humans
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Hypotension
(chemically induced, prevention & control)
- Infant, Newborn
- Plasma Substitutes
(therapeutic use)
- Pregnancy
- Pregnancy Outcome
- Prospective Studies
- Young Adult
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