Abstract | BACKGROUND: AIM: METHODS: Twelve patients with levator ani syndrome (>or=1 year) received anal intra sphincteric injections of 100 units of botulinum toxin A and placebo at 90-day intervals using EMG guidance. Daily frequency, severity, duration and intensity of pain (VAS) were recorded. Anorectal manometry, balloon expulsion and pudendal nerve latency tests were performed to examine the physiological changes and adverse effects. RESULTS: Seven patients (male/female = 4/3) completed the study and three had incomplete data, but all 10 underwent in an ITT analysis; two others dropped out. After administration of botulinum toxin, the mean frequency, intensity and duration of pain were unchanged (P = 0.31) compared with baseline. The 90-day mean VAS pain score was 6.79 +/- 0.27 vs. baseline score of 7.08 +/- 0.29 (P = 0.25). Anal sphincter pressures, rectal sensory thresholds, pudendal nerve latency and balloon expulsion times were unchanged after drug or placebo administration. CONCLUSIONS:
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Authors | S S C Rao, J Paulson, M Mata, B Zimmerman |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 29
Issue 9
Pg. 985-91
(May 01 2009)
ISSN: 1365-2036 [Electronic] England |
PMID | 19222415
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Aged
- Anal Canal
(drug effects)
- Botulinum Toxins, Type A
(administration & dosage)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Injections, Intramuscular
- Male
- Middle Aged
- Muscle, Smooth
(drug effects)
- Neuromuscular Agents
(therapeutic use)
- Pain Measurement
- Spasm
(drug therapy, prevention & control)
- Treatment Outcome
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