Abstract | BACKGROUND: METHODS: RESULTS: Characteristic dot-like Golgi staining was identified in 10/20 LyP (50%), 4/6 PC-ALCL (67%) and 9/12 MF-LCT (75%). Two of 12 PLEVA (17%), 1 of 12 ABR (8%) and 2 of 8 LR (25%) had lymphocytes (< 25%) with diffuse cytoplasmic staining. Dermal dendritic cells stained strongly for clusterin. High background staining occurred in some cases. CONCLUSION:
Clusterin immunostaining does not reliably distinguish between LyP, PC-ALCL or MF-LCT, but could distinguish LyP from its reactive histologic simulants.
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Authors | Stephen H Olsen, Linglei Ma, Bertram Schnitzer, Douglas R Fullen |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 36
Issue 3
Pg. 302-7
(Mar 2009)
ISSN: 1600-0560 [Electronic] United States |
PMID | 19220628
(Publication Type: Journal Article)
|
Chemical References |
- CLU protein, human
- Clusterin
- Ki-1 Antigen
- Neoplasm Proteins
|
Topics |
- Clusterin
(biosynthesis)
- Dendritic Cells
(metabolism, pathology)
- Dermis
(metabolism, pathology)
- Diagnosis, Differential
- Female
- Golgi Apparatus
(metabolism, pathology)
- Humans
- Ki-1 Antigen
- Lymphoma, T-Cell, Cutaneous
(metabolism, pathology)
- Male
- Neoplasm Proteins
(biosynthesis)
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