Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness.

Abstract

PURPOSE:

We tested the hypothesis that the expression of cortactin and survivin in renal cell carcinomas (RCCs) correlates with more advanced stages of the disease.

METHODS:

Immunohistochemical analysis of cortactin and survivin expression (scored on a scale of 0-400) was performed in 124 renal cell carcinomas including clear cell renal cell carcinoma (CRCC), papillary RCC (PRCC), CRCC with sarcomatoid differentiation (SRCC), chromophobe RCC (ChRCC), and CRCC with granular cell differentiation (GRCC).

RESULTS:

Higher cortactin scores in CRCC were significantly correlated with higher T (p = 0.021) and N stages (p = 0.036), and nuclear grade (p = 0.012). Higher cortactin immunostaining scores were associated with higher mortality (p = 0.035). In addition, the survivin scores were significantly higher in the more aggressive GRCC and SRCC than in CRCC, suggesting a significant role of survivin expression in transformation of tumor cells to a more malignant phenotype.

CONCLUSIONS:

Higher expression of cortactin and survivin significantly correlated with advanced clinicopathological stage. Our findings support the potential targeting of survivin and cortactin for the development of novel therapeutic strategies for renal cell carcinoma.

• Authors: Giueng-Chueng Wang, Po-Shiuan Hsieh, Hsian-He Hsu, Guang-Huan Sun, Shin Nieh, Cheng-Ping Yu, Jong-Shiaw Jin
• Journal: World journal of urology (World J Urol) Vol. 27 Issue 4 Pg. 557-63 (Aug 2009) ISSN: 1433-8726 [Electronic] Germany
• PMID: 19219613 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BIRC5 protein, human
• Biomarkers, Tumor
• Cortactin
• Inhibitor of Apoptosis Proteins
• Microtubule-Associated Proteins
• Survivin

Topics

• Biomarkers, Tumor
• Carcinoma, Renal Cell (diagnosis, metabolism, pathology)
• Cortactin (metabolism)
• Disease Progression
• Humans
• Inhibitor of Apoptosis Proteins
• Kidney Neoplasms (diagnosis, metabolism, pathology)
• Microarray Analysis
• Microtubule-Associated Proteins (metabolism)
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Severity of Illness Index
• Survivin