Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats.

Abstract	Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.
Authors	Zheng Wu, Qi Xu, Lei Zhang, Dehu Kong, Rong Ma, Liecheng Wang
Journal	Neurochemical research (Neurochem Res) Vol. 34 Issue 8 Pg. 1393-400 (Aug 2009) ISSN: 1573-6903 [Electronic] United States
PMID	19219549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anticonvulsants Excitatory Amino Acid Agonists Receptors, Kainic Acid Stilbenes Resveratrol Kainic Acid
Topics	Animals Anticonvulsants Behavior, Animal (drug effects) Blotting, Western Cell Death (drug effects) Electroencephalography (drug effects) Epilepsy, Temporal Lobe (chemically induced, pathology, prevention & control) Excitatory Amino Acid Agonists In Vitro Techniques Kainic Acid Male Mossy Fibers, Hippocampal (drug effects, pathology) Neurons (drug effects) Rats Rats, Wistar Receptors, Kainic Acid (drug effects) Resveratrol Seizures (chemically induced, prevention & control) Stilbenes (pharmacology)

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