[Expression of interleukin-1beta and tumor necrosis factor-alpha in the synovium and synovial fluid of patients with Kashin-Beck disease and osteoarthritis].

Abstract

OBJECTIVE:

To investigate the role of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis and progression of Kashin-Beck disease (KBD) and primary osteoarthritis (OA).

METHODS:

The synovium and synovial fluid of the knee joint were collected from 20 adult patients with KBD, 18 with OA and 19 with meniscus injury (controls). The expression of IL-1beta and TNF-alpha in the synovium were analyzed by immunohistochemistry staining, and the levels of IL-1beta and TNF-alpha in the synovial fluid were determined by enzyme-linked immunosorbent assay.

RESULT:

IL-1beta and TNF-alpha expressions in the synovium and their levels in the synovial fluid were significantly higher in patients with KBD and OA than in patients with meniscus injury (P<0.05), but comparable between KBD and OA groups (P>0.05).

CONCLUSION:

IL-1beta and TNF-alpha may play an important role in the pathogenesis and progression of KBD and OA.

• Authors: Zheng-ming Sun, Ming Ling, Miao Liu, Yin-gang Zhang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 29 Issue 1 Pg. 5-8 (Jan 2009) ISSN: 1673-4254 [Print] China
• PMID: 19218098 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1beta
• Tumor Necrosis Factor-alpha

Topics

• Adult
• Aged
• Cartilage, Articular (metabolism)
• Endemic Diseases
• Female
• Humans
• Interleukin-1beta (metabolism)
• Male
• Middle Aged
• Osteoarthritis (etiology, metabolism)
• Synovial Fluid (metabolism)
• Synovial Membrane (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)