Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells.

Abstract

A series of novel 3-aryl-1-(4-tert-butylbenzyl)-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound (E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide (3e) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer cells.

• Authors: Liang-Wen Zheng, Ling-Ling Wu, Bao-Xiang Zhao, Wen-Liang Dong, Jun-Ying Miao
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 17 Issue 5 Pg. 1957-62 (Mar 01 2009) ISSN: 1464-3391 [Electronic] England
• PMID: 19217789 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• (E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
• Antineoplastic Agents
• Hydrazines
• Pyrroles
• carbohydrazide

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Apoptosis
• Cell Line, Tumor
• Crystallography, X-Ray
• Humans
• Hydrazines (chemical synthesis, chemistry, pharmacology)
• Lung Neoplasms (pathology)
• Molecular Conformation
• Pyrroles (chemical synthesis, chemistry, pharmacology)