Abstract |
The plasma level of high-density lipoprotein cholesterol (HDL-C) is known to be inversely associated with cardiovascular risk. However, besides lifestyle, gene polymorphism may influence the HDL-C concentration. The aim of this study was to investigate the possibility of interactions between CETP, PPARA, APOE, and APOAI polymorphisms and HDL-C, apolipoprotein ( apo) A-I, lipoprotein (Lp) A-I, and Lp A-I:A-II in a sample selected from the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study population who remained free of cardiovascular events over 5 years of follow-up. Healthy individuals (857) were randomly selected for genotyping the PRIME study subjects. The population was selected so as to provide 25% of subjects in the lowest tertile of HDL-C (< or = 28 mg/dL) in the whole PRIME study sample, 25% of subjects in the highest tertile of HDL-C (> or = 73 mg/dL), and 50% of subjects in the medium tertile of HDL-C (28-73 mg/dL). Genotyping was performed by using a polymerase chain reaction system with predeveloped TaqMan allelic discrimination assay. The CETP A373P rare allele c was less frequent in the group of subjects with high HDL-C, apo A-I, Lp A-I, and Lp A-I:A-II concentrations. Apolipoprotein A-I and Lp A-I were also found to be higher in the presence of the epsilon2 allele coding for APOE. The effect of the CETP A373P rare allele c on HDL-C was independent of all tested parameters except triglycerides. The respective effect of these polymorphisms and triglycerides on cardiovascular risk should be evaluated prospectively.
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Authors | Hong Quang Do, Hassan Nazih, Gérald Luc, Dominique Arveiler, Jean Ferrières, Alun Evans, Philippe Amouyel, François Cambien, Pierre Ducimetière, Jean-Marie Bard |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 58
Issue 3
Pg. 283-9
(Mar 2009)
ISSN: 1532-8600 [Electronic] United States |
PMID | 19217440
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoprotein A-I
- Apolipoprotein A-II
- Apolipoproteins E
- Cholesterol Ester Transfer Proteins
- Cholesterol, HDL
- PPAR alpha
- DNA
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Topics |
- Apolipoprotein A-I
(blood, genetics)
- Apolipoprotein A-II
(blood)
- Apolipoproteins E
(genetics)
- Cholesterol Ester Transfer Proteins
(genetics)
- Cholesterol, HDL
(blood)
- Cohort Studies
- DNA
(blood, genetics)
- France
- Genotype
- Humans
- Life Style
- Male
- Middle Aged
- Myocardial Infarction
(blood, epidemiology, genetics)
- Northern Ireland
- PPAR alpha
(genetics)
- Polymorphism, Genetic
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