Abstract | OBJECTIVES: METHODS: RESULTS:
Heat shock protein 27 levels were significantly higher in cancer and pancreatitis compared with control (P < 0.001 for both), but no significant difference was noted between cancer and pancreatitis (P = 0.978). By logistic regression, HSP27 was a significant predictor of differentiation between cancer and control (P < 0.0001) but not between cancer and pancreatitis (P = 0.885). At a cutoff of 1650 ng/L, the sensitivity and specificity for differentiating cancer from healthy control were 62.1% and 95.1%, respectively. Receiver operating characteristic analyses showed a greater area under curve for CA19-9 compared with HSP27 in differentiating between cancer and control (0.92 and 0.84, respectively, P = 0.014). CONCLUSIONS:
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Authors | Wei-Chih Liao, Ming-Shiang Wu, Hsiu-Po Wang, Yu-Wen Tien, Jaw-Town Lin |
Journal | Pancreas
(Pancreas)
Vol. 38
Issue 4
Pg. 422-6
(May 2009)
ISSN: 1536-4828 [Electronic] United States |
PMID | 19214136
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- CA-19-9 Antigen
- HSP27 Heat-Shock Proteins
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- CA-19-9 Antigen
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- HSP27 Heat-Shock Proteins
(blood)
- Humans
- Male
- Middle Aged
- Pancreatic Neoplasms
(blood, diagnosis)
- Pancreatitis, Chronic
(blood, diagnosis)
- Predictive Value of Tests
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