Abstract | OBJECTIVES: MATERIAL AND METHODS: Twenty-nine patients with TS who received LEV to control their tics were admitted to the study. The authors recorded the following variables: initial status (Yale Global Tic Severity Scale - YGTSS - and the scale of Modified Clinical Global Impression -MCGI), the clinical status at 3 months using the same scales, and clinical/medical impression of improvement. RESULTS: The mean age of the patients studied was 12 years; 25 males (86%) and 4 females (14%). Participants received 800-2000 mg/day of LEV. Of the 29 patients, 21 children (72%) improved according to YGTSS and MCGI scores. Mean YGTSS Total Tic Score at baseline and after treatment with LEV were 67 and 44, respectively. The statistical analysis confirmed a significant improvement with a p-value of <0.001 on the YGTSS and MCGI. In 3 cases, treatment was suspended due to adverse effects. CONCLUSIONS: Treatment with LEV can constitute a treatment option for tics in patients with TS. Double-blind trials of longer duration are needed in larger samples in order to establish both the benefit, as well as what patients are eligible for treatment.
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Authors | Alberto Fernández-Jaén, Daniel Martín Fernández-Mayoralas, Nuria Muñoz-Jareño, Beatriz Calleja-Pérez |
Journal | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
(Eur J Paediatr Neurol)
Vol. 13
Issue 6
Pg. 541-5
(Nov 2009)
ISSN: 1532-2130 [Electronic] England |
PMID | 19211282
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Nootropic Agents
- Levetiracetam
- Piracetam
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Topics |
- Adolescent
- Child
- Dose-Response Relationship, Drug
- Female
- Humans
- Levetiracetam
- Male
- Nootropic Agents
(therapeutic use)
- Piracetam
(analogs & derivatives, therapeutic use)
- Prospective Studies
- Psychiatric Status Rating Scales
- Severity of Illness Index
- Tourette Syndrome
(drug therapy)
- Treatment Outcome
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