HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic.

Abstract	Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLA-B*2709 positive subject who underwent IFN-alpha treatment for essential thrombocythemia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.
Authors	A Cauli, A Vacca, G Dessole, M T Fiorillo, G Porru, V Ibba, V Mura, M Piga, R Sorrentino, A Mathieu
Journal	Clinical and experimental rheumatology (Clin Exp Rheumatol) 2008 Nov-Dec Vol. 26 Issue 6 Pg. 1111-2 ISSN: 0392-856X [Print] Italy
PMID	19210881 (Publication Type: Case Reports, Journal Article)
Chemical References	HLA-B Antigens Immunologic Factors Interferon-alpha
Topics	Adult Arthritis (chemically induced, genetics) Female Genetic Predisposition to Disease HLA-B Antigens (genetics) Humans Immunologic Factors (adverse effects) Interferon-alpha (adverse effects) Sacroiliac Joint Spondylitis, Ankylosing (genetics) Thrombocythemia, Essential (drug therapy, genetics)

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