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Seton drainage and fibrin glue injection for complex anal fistulas.

AbstractOBJECTIVE:
The study aimed to evaluate the efficacy of fibrin glue in the treatment of complex anal fistula.
METHOD:
Thirty consecutive patients with a complex anal fistula underwent glue instillation after an 8 week period of seton drainage. Cure was defined as complete closure of any secondary opening, absence of fistula seepage, and no abscess formation.
RESULTS:
The mean age of the patients (15 males) was 40.5 (range, 22.8-69.1) years. The mean duration of follow-up was 11.7 (range, 0.2-33.5) months. Complete closure of the fistula was achieved in 17 patients at 1 month but in two patients a delayed abscess occurred. At the end of follow-up, 15 (50%) patients were considered to have been cured. The success rate was no different in cases of Crohn's disease or when postoperative antibiotic therapy was given. There was, however, a significant difference in success following regional vs general anaesthesia (68.4 vs 18.2% success, P = 0.02).
CONCLUSION:
Fibrin glue cured 50% of our first 30 patients, and regional anaesthesia was predictive of success.
AuthorsV de Parades, H Safa Far, I Etienney, J-D Zeitoun, P Atienza, P Bauer
JournalColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (Colorectal Dis) Vol. 12 Issue 5 Pg. 459-63 (May 2010) ISSN: 1463-1318 [Electronic] England
PMID19210300 (Publication Type: Journal Article)
Chemical References
  • Fibrin Tissue Adhesive
  • Tissue Adhesives
Topics
  • Adult
  • Aged
  • Combined Modality Therapy
  • Drainage
  • Female
  • Fibrin Tissue Adhesive (administration & dosage)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Rectal Fistula (surgery, therapy)
  • Tissue Adhesives (administration & dosage)
  • Young Adult

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