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Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1.

Abstract
Wilms' tumour suppressor gene 1 (WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms' tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could have implications for the screening of children with MPGN.
AuthorsDetlef Bockenhauer, William van't Hoff, Gil Chernin, Saskia F Heeringa, Neil J Sebire
JournalPediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 24 Issue 7 Pg. 1399-401 (Jul 2009) ISSN: 1432-198X [Electronic] Germany
PMID19205749 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Immunosuppressive Agents
  • Vincristine
Topics
  • Antineoplastic Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Female
  • Genes, Wilms Tumor
  • Glomerulonephritis, Membranoproliferative (complications, genetics, physiopathology)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Infant
  • Kidney Transplantation
  • Mutation
  • Nephrectomy
  • Vincristine (therapeutic use)
  • Wilms Tumor (complications, genetics, surgery)

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