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The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells.

Abstract
The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.
AuthorsNao Inoue, Naomi Yamano, Kotaro Sakata, Koji Nagao, Yoichiro Hama, Teruyoshi Yanagita
JournalBioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 73 Issue 2 Pg. 447-9 (Feb 2009) ISSN: 1347-6947 [Electronic] England
PMID19202270 (Publication Type: Journal Article)
Chemical References
  • Apolipoprotein B-100
  • Cholesterol Esters
  • Lipids
  • Triglycerides
  • porphyran
  • Sulfur
  • Sepharose
Topics
  • Animals
  • Apolipoprotein B-100 (metabolism)
  • Cattle
  • Cell Line, Tumor
  • Cholesterol Esters (biosynthesis)
  • Humans
  • Lipids (biosynthesis)
  • Seaweed (chemistry)
  • Sepharose (analogs & derivatives, pharmacology)
  • Sulfur (chemistry)
  • Triglycerides (biosynthesis)

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