[Clomiphene, ovarian hyperstimulation syndrome and pregnancy].

Abstract

In case of an ovarian hyperstimulation syndrome surgical treatment causes the regress of symptoms much faster than pharmacotherapy--during the resection of an ovary the concentration of estrogenes in blood is effectively reduced. Frequent use of ovulation inductors (Clomiphene Gonadotrop(h)in) is accompanied by ovarian hyperstimulation syndrome. It is characterized by the increase of sizes of ovaries; the formation of ascites and hydrothorax, by the thromboemboly of main blood vessels and etc. Clomiphene accelerates the maturation process of follicles, but contributes to the increase of concentration of oncomarker CA-125 in blood. This makes it difficult to verify the diagnosis of ovary cancer, particularly among pregnants. The case report of infertility treatment with Clomiphene is depicted. Woman became pregnant after three courses of infertility treatment, but pregnancy was complicated with cardiac and lung insufficiency; the suspicion of stage III ovarian cancer aroused. Serious threat to health of a woman resulted in prevention of pregnancy. Right side adnexectomy was conducted. Surgical treatment led to improvement and after four years the patient delivered a healthy child.

• Authors: M D Samsonia, E E Lesnovskaia, M A Kandelaki
• Journal: Georgian medical news (Georgian Med News) Issue 166 Pg. 26-9 (Jan 2009) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 19202213 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Estrogen Antagonists
• Estrogens
• Clomiphene

Topics

• Clomiphene (therapeutic use)
• Estrogen Antagonists (therapeutic use)
• Estrogens (blood)
• Female
• Humans
• Infant, Newborn
• Infertility, Female (blood, drug therapy, etiology)
• Ovarian Hyperstimulation Syndrome (complications, drug therapy, surgery)
• Pregnancy
• Pregnancy Outcome
• Young Adult