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Gonadotropin-releasing hormone antagonist use in controlled ovarian stimulation and intrauterine insemination cycles in women with polycystic ovary syndrome.

AbstractOBJECTIVE:
To observe the effects of ganirelix on controlled ovarian stimulation and intrauterine insemination (COS/IUI) cycles in women with polycystic ovary syndrome (PCOS).
DESIGN:
Prospective, randomized, controlled clinical study.
SETTING:
An academic clinical research center.
PATIENT(S):
Women with PCOS and anovulatory infertility undergoing COS/IUI.
INTERVENTION(S):
Recombinant FSH therapy was started on day 3. In women assigned to the control group (n = 47), treatment was continued up to the day of hCG administration. In patients assigned to receive GnRH antagonist (n = 42), ganirelix was added when the leading follicle was > or =14 mm.
MAIN OUTCOME MEASURE(S):
Pregnancy rates, serum E(2), P, and LH levels, and follicle numbers at hCG day, prevalence of premature luteinization, and cost of stimulation.
RESULT(S):
Serum E(2), P, and LH levels were significantly lower in the ganirelix group. Although premature luteinization and cycle cancellation was encountered less in the ganirelix group, the pregnancy rates per cycle were similar (15.4% vs. 10.7%). Patients would pay 6,153 dollars more for each pregnancy when using ganirelix.
CONCLUSION(S):
Gonadotropin-releasing hormone antagonist resulted in more monofollicular development, less premature luteinization, and less cycle cancellation in IUI cycles of patients with PCOS; however, the cost of stimulation increased without an improvement in pregnancy rates.
AuthorsDevrim Ertunc, Ekrem C Tok, Aysun Savas, Ilay Ozturk, Saffet Dilek
JournalFertility and sterility (Fertil Steril) Vol. 93 Issue 4 Pg. 1179-84 (Mar 01 2010) ISSN: 1556-5653 [Electronic] United States
PMID19200979 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
CopyrightCopyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Hormone Antagonists
  • Gonadotropin-Releasing Hormone
  • ganirelix
Topics
  • Adult
  • Female
  • Gonadotropin-Releasing Hormone (analogs & derivatives, antagonists & inhibitors, blood, pharmacology, therapeutic use)
  • Hormone Antagonists (pharmacology, therapeutic use)
  • Humans
  • Infertility, Female (blood, drug therapy, etiology)
  • Insemination, Artificial, Homologous (methods)
  • Male
  • Ovulation Induction (methods)
  • Polycystic Ovary Syndrome (blood, complications, drug therapy)
  • Pregnancy
  • Prospective Studies
  • Young Adult

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