Treatment of painful diabetic neuropathy with capsaicin 0.075%.

Abstract

An 8-week, double-blind, vehicle-controlled study was conducted to determine the effectiveness of topical capsaicin 0.075% cream in relieving pain associated with diabetic neuropathy. Patients were selected who experienced moderate to very severe pain, which interfered with sleep or activities on a daily basis, and who were unresponsive or intolerant to conventional therapy. The results after 8 weeks showed a statistically significant difference in favor of the capsaicin-treated patients, with 90% of these patients improved. The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy.

• Authors: N M Scheffler, P L Sheitel, M N Lipton
• Journal: Journal of the American Podiatric Medical Association (J Am Podiatr Med Assoc) Vol. 81 Issue 6 Pg. 288-93 (Jun 1991) ISSN: 8750-7315 [Print] United States
• PMID: 1920093 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Capsaicin

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Capsaicin (administration & dosage, therapeutic use)
• Diabetic Neuropathies (complications, diagnosis)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Pain (diagnosis, drug therapy, etiology)
• Pain Measurement