Abstract |
There are no data currently available on gender and racial variation in smallpox vaccine immune responses. We recruited 1076 healthy adults 18-40 years old who received one dose of the US-licensed smallpox vaccine (Dryvax). Vaccinia neutralizing antibody titers in each subject's serum were determined using a high throughput neutralization assay based on a recombinant, beta-gal expressing vaccinia virus. Results are reported as the serum dilution inhibiting 50% of virus activity (ID(50)). The median ID(50) for all subjects was 132.2 (inter-quartile range (IQR)=78.8, 205.6). While no significant differences were observed with race and ethnicity, females had significantly higher neutralizing antibody titers than males (158.5 [93.2, 255.8] vs. 124.1 [75.2, 185.9]; p<0.0001). As expected, time since vaccination was also associated with variations in neutralizing antibody titers in our subjects. These data indicate that neutralizing antibody titers following primary smallpox vaccination vary by gender.
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Authors | Richard B Kennedy, Inna G Ovsyannikova, V Shane Pankratz, Robert A Vierkant, Robert M Jacobson, Margaret A K Ryan, Gregory A Poland |
Journal | Vaccine
(Vaccine)
Vol. 27
Issue 25-26
Pg. 3319-23
(May 26 2009)
ISSN: 0264-410X [Print] Netherlands |
PMID | 19200827
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antibodies, Viral
- Smallpox Vaccine
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Topics |
- Adolescent
- Adult
- Antibodies, Viral
(blood)
- Female
- Humans
- Male
- Neutralization Tests
- Sex Characteristics
- Smallpox Vaccine
(immunology)
- Vaccination
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