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The efficacy of a single dose of intravenous ferric carboxymaltose (Ferinject) on anaemia in a pre-dialysis population of chronic kidney disease patients.

Abstract
Anaemia due to chronic kidney disease (CKD) is common and may be managed with erythropoiesis stimulating agents and/or iron preparations. Iron preparations may be administered orally, intravenously or by intramuscular injection. Oral preparations pose a significant tablet burden on patients who are often taking multiple medications and may have undesirable gastrointestinal side effects. The existing intravenous preparation Venofer requires multiple doses of drug (typically 100-200 mg) at multiple clinic visits. The preparation Cosmofer may be given as a single dose, but this requires four to six hours to administer. For these reasons, their use in pre-dialysis patients remains limited in practice. The new intravenous iron preparation Ferric Carboxymaltose (Ferinject) may be given as a single dose of up to 1000 mg (but not exceeding 15 mg/kg/week) as an infusion over 6-15 minutes. This offers a significant advance in the management of these patients. We describe our initial experience with using this drug in a non-dialysis patient population with chronic kidney disease.
AuthorsSenyo Tagboto, Liz Cropper, June Turner, Karen Pugh-Clarke
JournalJournal of renal care (J Ren Care) Vol. 35 Issue 1 Pg. 18-23 (Mar 2009) ISSN: 1755-6678 [Print] United States
PMID19200274 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Ferric Compounds
  • Hematinics
  • ferric carboxymaltose
  • Maltose
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia (etiology, prevention & control)
  • Female
  • Ferric Compounds (administration & dosage)
  • Hematinics (administration & dosage)
  • Humans
  • Infusions, Intravenous
  • Male
  • Maltose (administration & dosage, analogs & derivatives)
  • Middle Aged
  • Premedication
  • Renal Dialysis
  • Renal Insufficiency, Chronic (complications, drug therapy)

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