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Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.

AbstractBACKGROUND:
Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.
METHODS:
To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT).
RESULTS:
A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations.
CONCLUSION:
The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.
AuthorsXiaohui Xu, Jonathan Mill, Bo Sun, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, Philip Asherson
JournalBMC psychiatry (BMC Psychiatry) Vol. 9 Pg. 3 (Feb 05 2009) ISSN: 1471-244X [Electronic] England
PMID19196467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dopamine Plasma Membrane Transport Proteins
Topics
  • Adolescent
  • Adult
  • Attention Deficit Disorder with Hyperactivity (genetics)
  • Child
  • Child, Preschool
  • Dopamine Plasma Membrane Transport Proteins (genetics)
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic
  • Promoter Regions, Genetic
  • Risk Factors

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