Abstract | BACKGROUND:
Attention deficit hyperactivity disorder ( ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD. METHODS: To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT). RESULTS: A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations. CONCLUSION: The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.
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Authors | Xiaohui Xu, Jonathan Mill, Bo Sun, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, Philip Asherson |
Journal | BMC psychiatry
(BMC Psychiatry)
Vol. 9
Pg. 3
(Feb 05 2009)
ISSN: 1471-244X [Electronic] England |
PMID | 19196467
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Plasma Membrane Transport Proteins
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Topics |
- Adolescent
- Adult
- Attention Deficit Disorder with Hyperactivity
(genetics)
- Child
- Child, Preschool
- Dopamine Plasma Membrane Transport Proteins
(genetics)
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Factors
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