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Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans - one high in protein and one nutritionally balanced.

AbstractBACKGROUND:
Little is known about the relative efficacy of high-protein vs. conventional diet plans that include partial meal replacements on body fat loss in obese subjects with metabolic syndrome.
OBJECTIVE:
We aimed to evaluate the efficacy of two low-calorie diets with partial meal replacement plans-a high-protein plan (HP) and a nutritionally balanced conventional (C) plan-on reducing obesity in obese subjects with metabolic syndrome.
DESIGN:
In a 12-week, double-blind study, we randomised 75 participants to either the HP- or the C-plan group. We recorded key metrics at 0 and 12 weeks.
RESULTS:
The overall mean weight loss was 5 kg in the HP-plan group and 4.9 kg in the C-plan group (p = 0.72). Truncal fat mass decreased 1.6 kg in the HP-plan group (p < 0.05) and 1.5 kg in the C-plan group (p < 0.05), while whole body fat mass decreased 2.5 kg in the HP-plan group (p < 0.05) and 2.3 kg in the C-plan group (p < 0.05). Between-group losses did not differ significantly for truncal (p = 0.52) or whole body (p = 0.77) fat mass. Among subjects with > or = 70% dietary compliance, however, truncal and whole body fat mass decreased more in the HP-plan group (Delta 2.2 kg and Delta 3.5 kg respectively) than in the C-plan group (Delta 1.3 kg and Delta 2.3 [corrected] kg respectively) (p < 0.05).
CONCLUSION:
The HP- and C-plans had a similar effect on weight and abdominal fat reduction, but the HP-plan was more effective in reducing body fat among compliant subjects.
AuthorsK Lee, J Lee, W K Bae, J K Choi, H J Kim, B Cho
JournalInternational journal of clinical practice (Int J Clin Pract) Vol. 63 Issue 2 Pg. 195-201 (Feb 2009) ISSN: 1742-1241 [Electronic] India
PMID19196357 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dietary Proteins
Topics
  • Abdominal Fat (pathology)
  • Adiposity
  • Body Mass Index
  • Body Weight (physiology)
  • Caloric Restriction (methods)
  • Diet, Reducing (methods)
  • Dietary Proteins (administration & dosage)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Metabolic Syndrome (complications, pathology)
  • Middle Aged
  • Obesity (complications, diet therapy, pathology)
  • Patient Compliance

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