Lesions of pemphigus vulgaris on irradiated skin.

Abstract

Summary Pemphigus vulgaris (PV) is an autoimmune blistering disease produced by IgG autoantibodies against desmoglein (Dsg)3. Lesions on the skin and mucosa can, in rare cases, be induced by radiotherapy. We report a patient with a history of microprolactinoma and PV, who had only oral lesions from the beginning of her illness but 2 months after treatment with radiotherapy for a breast neoplasia, developed skin lesions limited to the irradiated area. Over the following few months, she also developed autoantibodies against Dsg1.

• Authors: L Aguado, M Marquina, M Pretel, G Ruiz-Carrillo, A España
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 34 Issue 5 Pg. e148-50 (Jul 2009) ISSN: 1365-2230 [Electronic] England
• PMID: 19196299 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Desmoglein 1

Topics

• Adult
• Autoantibodies (blood)
• Breast Neoplasms (radiotherapy)
• Desmoglein 1 (immunology)
• Female
• Humans
• Pemphigus (etiology, immunology)
• Radiation Injuries (etiology, immunology)
• Radiotherapy (adverse effects)