| Abstract | Idiopathic nephrotic syndrome (INS) is the most frequent glomerular nephropathy in children. The response to corticoids distinguishes steroid-sensitive nephrotic syndrome (SSINS), by far the most frequent (90% of cases), from steroid-resistant nephrotic syndrome (SRINS). The steroid resistance of nephrotic syndrome is defined by the absence of remission after a full dose of oral corticosteroid therapy for 1 month followed by 3 pulses of intravenous methylprednisolone. Actually, INS constitutes a heterogeneous nosologic entity. Currently, within the SRINS, there are 2 forms that vary greatly in their physiopathology and prognostics: immunologic or sporadic forms, which can be improved by immunosuppressive agents and the genetic or familial forms, which do not respond to any immunosuppressive therapy and usually evolve to end-stage renal insufficiency. In these genetic forms, renal transplantation is the only therapeutic alternative. The aim of this article is to review treatment of SRINS and to propose a management strategy. |
| Authors | J Chemli, A Harbi
(Affiliation: Service de néphrologie pédiatrique, CHU Sahloul, Sousse 4054, Tunisie. jalel_chemli at yahoo.fr)
|
| Journal | Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
(Arch Pediatr)
Vol. 16
Issue 3
Pg. 260-8
(Mar 2009)
ISSN: 0929-693X [Print] France |
| Vernacular Title | Traitement du syndrome néphrotique idiopathique corticorésistant. |
| PMID | 19195856
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
- Adrenal Cortex Hormones
- Enzyme Inhibitors
- Immunosuppressive Agents
|
| Topics |
- Adrenal Cortex Hormones
(administration & dosage, adverse effects)
- Drug Resistance
- Enzyme Inhibitors
(therapeutic use)
- Humans
- Immunosorbent Techniques
- Immunosuppressive Agents
(therapeutic use)
- Kidney Transplantation
- Nephrotic Syndrome
(therapy)
- Plasmapheresis
|
