Efficacy of etravirine for treatment of acute HIV meningoencephalitis.

Abstract

We describe a patient with human immunodeficiency virus (HIV) and hepatitis C virus coinfection who experienced recurrent episodes of acute HIV meningoencephalitis. The addition of etravirine to the therapeutic regimen completely resolved symptoms, and HIV was no longer detected in cerebrospinal spinal fluid specimens. Etravirine has a satisfactory safety profile and, in this case, was a durable alternative therapy for HIV meningoencephalitis.

• Authors: Carine Couzigou, Sophie Seang, Laurence Morand-Joubert, Anne-Marie Roque-Afonso, Lélia Escaut, Daniel Vittecoq
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 48 Issue 6 Pg. e62-5 (Mar 15 2009) ISSN: 1537-6591 [Electronic] United States
• PMID: 19193114 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• Nitriles
• Pyridazines
• Pyrimidines
• etravirine

Topics

• Adult
• Anti-HIV Agents (therapeutic use)
• Cerebrospinal Fluid (virology)
• Female
• HIV (isolation & purification)
• HIV Infections (complications, drug therapy)
• Hepatitis C (complications)
• Humans
• Meningoencephalitis (drug therapy)
• Nitriles
• Pyridazines (therapeutic use)
• Pyrimidines
• Treatment Outcome