| Abstract | Tumor necrosis factor (TNF)-alpha antagonists have considerably improved the therapeutic approach to chronic inflammatory disorders including psoriasis vulgaris. Recently, some cases of highly aggressive hepatosplenic T-cell lymphoma (HSTCL) have developed in patients with inflammatory bowel diseases (IBD) being treated with infliximab or adalimumab. Analysis of the published data suggests that the emergence of HSTCL is favored by the combination of purine analogues and infliximab or adalimumab in the therapy of a granulomatous inflammation involving Vdelta1(+)gammadelta T cells. Because psoriasis vulgaris is different from IBD in regard to the type of inflammation, the concomitant therapies used and the tissue-specific subsets of gammadelta T cells, the use of infliximab or adalimumab in psoriasis may not necessarily be associated with an increase in the risk of HSTCL. |
| Authors | Marc Beyer, Matthias Steinhoff, Ioannis Anagnostopoulos, Chalid Assaf, Wolfram Sterry
(Affiliation: Department of Dermatology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Berlin D-10117, Germany. marc.beyer at charite.de)
|
| Journal | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
(J Dtsch Dermatol Ges)
Vol. 7
Issue 3
Pg. 191-4
(Mar 2009)
ISSN: 1610-0387 [Electronic] Germany |
| PMID | 19192165
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Anti-Inflammatory Agents
- Tumor Necrosis Factor-alpha
|
| Topics |
- Anti-Inflammatory Agents
(adverse effects)
- Humans
- Lymphoma, T-Cell
(chemically induced)
- Psoriasis
(complications, drug therapy)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
|
