Abstract | OBJECTIVE: DESIGN: Maximal inspiratory pressure, inspiratory pressure 0.1 sec after the onset of inspiration (P 0.1), and the breathing pattern during spontaneous breathing were measured in 46 subjects with Duchenne muscular dystrophy and in 46 healthy males of the same age. TT MUS (TT MUS = T I/T TOT x P I/MIP) was determined by calculating P I from P 0.1 (P I = 5 x P 0.1 x T I). The data were compared with normal values and related to age and ventilator use. RESULTS: TT MUS was significantly higher in the entire Duchenne muscular dystrophy group than in controls (0.21 +/- 0.11 vs. 0.06 +/- 0.02, P < 0.001) and increased with age in the patients (P < 0.001). TT MUS was significantly higher in subjects ventilated 8-20 hrs per day than in nocturnal-only users and in patients ventilated >20 hrs per day than in those ventilated 8-20 hrs per day (P < 0.001). TT MUS surpassed 0.23 in 95% of subjects ventilated 8-20 hrs. TT MUS exceeded 0.37 in 95% of individuals ventilated >20 hrs per day, whereas it was less than this value in 95% of patients ventilated 8-20 hrs. CONCLUSIONS:
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Authors | Andreas Hahn, Barbara Duisberg, Bernd A Neubauer, Ulrich Stephani, Yves Rideau |
Journal | American journal of physical medicine & rehabilitation
(Am J Phys Med Rehabil)
Vol. 88
Issue 4
Pg. 322-7
(Apr 2009)
ISSN: 1537-7385 [Electronic] United States |
PMID | 19190489
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Case-Control Studies
- Disease Progression
- Forced Expiratory Volume
- Humans
- Inhalation
- Lung Volume Measurements
- Male
- Muscle Fatigue
- Muscle Tonus
- Muscular Dystrophy, Duchenne
(diagnosis, physiopathology)
- Respiratory Insufficiency
- Severity of Illness Index
- Time Factors
- Vital Capacity
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