Abstract |
Effective and affordable treatment of malaria is critical in the face of resistance of Plasmodium falciparum to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). We conducted a randomized controlled trial comparing the efficacy of chlorproguanil-dapsone (CD) with a combination SP plus CQ in children in Nigeria less than five years of age with malaria. Of 264 children enrolled, 122 (89.7%) and 118 (92.2%) completed the study in the SP + CQ and CD groups, respectively. By day 3, 96 (78.7%) and 94 (79.7%) had cleared their parasitemia (P = 0.79), and 107 (87.7%) and 109 (92.4%) were symptom free (P = 0.32) in the SP + CQ and CD groups, respectively. Adequate clinical and parasitologic response at day 14 occurred in 111 (94.1%; 95% confidence interval [CI] = 91.6-95.7%) in the CD group and 113 (92.6%; 95% CI = 89.9-94.3%) in the SP + CQ group (P = 0.85). SP + CQ and CD had similar antimalarial efficacy and still provide affordable treatment of uncomplicated malaria in northcentral Nigeria.
|
Authors | Oluwagbenga Ogunfowokan, Musa Dankyau, Aboi J K Madaki, Tom D Thacher |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 80
Issue 2
Pg. 199-201
(Feb 2009)
ISSN: 1476-1645 [Electronic] United States |
PMID | 19190213
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antimalarials
- Drug Combinations
- chloroguanil, dapsone drug combination
- fanasil, pyrimethamine drug combination
- Sulfadoxine
- Chloroquine
- Dapsone
- Proguanil
- Pyrimethamine
|
Topics |
- Animals
- Antimalarials
(therapeutic use)
- Child, Preschool
- Chloroquine
(therapeutic use)
- Dapsone
(therapeutic use)
- Drug Combinations
- Drug Therapy, Combination
- Female
- Humans
- Infant
- Malaria, Falciparum
(drug therapy, parasitology)
- Male
- Nigeria
- Parasitemia
(drug therapy, parasitology)
- Plasmodium falciparum
(drug effects)
- Proguanil
(analogs & derivatives, therapeutic use)
- Pyrimethamine
(therapeutic use)
- Sulfadoxine
(therapeutic use)
- Treatment Outcome
|