Abstract | BACKGROUND: METHODS: RESULTS: Significant positive correlations were seen when AR and AR-dependent PSA, and ERalpha and ERalpha-dependent PGR were compared, indicating a representative population of RNA transcripts. ERbeta gene expression was significantly over-expressed in the cancer group compared with benign controls (P < 0.01). In contrast, PGR expression was significantly down-regulated in the cancer group (P < 0.05). There were no significant differences in AR, ERalpha or PSA expression between the groups. This study represents the first to show an upregulation of ERbeta gene expression in laser microdissected prostate cancer specimens. CONCLUSIONS: In concert with recent studies the findings suggest differential production of ERbeta splice variants, which may play important roles in the genesis of prostate cancer.
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Authors | Thomas J Walton, Geng Li, Thomas A McCulloch, Rashmi Seth, Desmond G Powe, Michael C Bishop, Robert C Rees |
Journal | The Prostate
(Prostate)
Vol. 69
Issue 8
Pg. 810-9
(Jun 01 2009)
ISSN: 1097-0045 [Electronic] United States |
PMID | 19189301
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2009 Wiley-Liss, Inc. |
Chemical References |
- DNA Primers
- DNA, Neoplasm
- Estrogen Receptor alpha
- RNA, Neoplasm
- Receptors, Androgen
- Receptors, Estrogen
- Receptors, Progesterone
- Prostate-Specific Antigen
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Topics |
- DNA Primers
- DNA, Neoplasm
(genetics)
- Estrogen Receptor alpha
(genetics)
- Gene Expression Regulation, Neoplastic
- Humans
- Lasers
- Male
- Microdissection
- Polymerase Chain Reaction
- Prostate
(physiology)
- Prostate-Specific Antigen
(genetics)
- Prostatectomy
- Prostatic Neoplasms
(genetics, pathology, surgery)
- RNA, Neoplasm
(genetics, isolation & purification)
- Receptors, Androgen
(genetics)
- Receptors, Estrogen
(genetics)
- Receptors, Progesterone
(genetics)
- Reference Values
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription, Genetic
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